See what the experts say on LYMA Laser technology and LLLT in this peer-reviewed evidence.
There are thousands of scientific journals published on the subject of Low-Level Laser Therapy (LLLT) and its regenerative and healing properties. See what your peers are saying on LYMA Laser technology and LLLT in just some of the peer-reviewed evidence for near-infrared laser in plastic surgery.
The science and further reading
Glass G.E. Photobiomodulation: A review of the molecular evidence for low level light therapy. Journal of Plastic, Reconstructive & Aesthetic Surgery 2021. Read on JPRAS
Hode et al. The importance of coherence in phototherapy. Mechanisms for Low-Light Therapy IV 2009. Read the SPIE paper
Karu T. Primary and secondary mechanisms of action of visible to near-IR radiation on cells. Journal of Photochemistry and Photobiology 1998. Read on PubMed
Glass G.E. Photobiomodulation: The Clinical Applications of Low-Level Light Therapy. Oxford University Press. View full text
Mechanistic summaries
Avci et al. Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring. Seminars in Cutaneous Medicine and Surgery, 2013. Read on NIH
da Silva et al. Laser therapy in the tissue repair process: a literature review. Photomedicine and Laser Surgery, 2010. Read on PubMed
Chung et al. The nuts and bolts of low-level laser therapy. Annals of Biomedical Engineering, 2012. Read on PubMed
Avci et al. Low-level laser therapy for treatment of hair loss. Lasers in Surgery and Medicine, 2014. Read more
Houreld N.N. The use of lasers and light sources in skin rejuvenation. Clinics in Dermatology, 2019. View article
Pre-clinical studies
Gupta et al. Effect of red and near-infrared wavelengths on wound healing in mice. Lasers in Medical Science, 2014. Read on PubMed
Ma et al. Effect of low-level laser therapy on collagen synthesis in fibroblasts. Journal of Wound Management and Research, 2018.
Clinical trials
Hopkins et al. LLLT facilitates superficial wound healing: a triple-blind, sham-controlled study. Journal of Athletic Training, 2004. View trial
Kajagar et al. Efficacy of LLLT on wound healing in diabetic foot ulcers. Indian Journal of Surgery, 2012. Read trial
Gupta et al. Low energy photon therapy in venous leg ulcers: a placebo-controlled study. Dermatologic Surgery, 1998. Read study
General reading
Avci et al. Primary and secondary mechanisms of action of visible to near-IR radiation on cells. Semin Cutan Med Surg, 2013.
Karu T. LLLT in skin: stimulating, healing, restoring. Journal of Photochemistry and Photobiology, 1998.
Photobiomodulation: A systematic review of the oncologic safety of LLLT for aesthetic skin rejuvenation. Aesthetic Surgery Journal Open Forum, 2023. Read review
Learn more about the technology used in the LYMA Laser PRO today.
Frequently asked questions about the science behind the LYMA Laser PRO
Is there peer-reviewed research on LYMA's laser technology?
Yes. A 2025 peer-reviewed study in Aesthetic Surgery Journal Open Forum found LYMA's 808nm laser changed the expression of 45 genes in human skin, compared with one for an LED device of similar wavelength. Read the clinical study.
How does near-infrared light affect the skin?
Near-infrared light is absorbed by cells, mainly by an enzyme in the mitochondria called cytochrome c oxidase, which influences how cells produce energy. This is the basis of photobiomodulation. Read about photobiomodulation.
How do at-home skincare devices compare by technology and evidence?
LED masks are widely available, microcurrent has a smaller body of studies, radiofrequency uses heat, and low-level laser therapy has decades of medical research. Always check each device's FDA-cleared indication. Read the truth about LED devices.
Are at-home beauty devices regulated?
In the US, many light-based beauty devices are regulated by the FDA as medical devices and need 510(k) clearance for specific uses. Both LYMA Lasers are FDA-cleared for the treatment of facial wrinkles at home or in clinic. Read the NIRA comparison.
What does "clinically studied" mean for a beauty device?
It means the device, or its technology, has been tested in a study. It does not mean every marketing claim is proven, so check what was measured and on whom. Read whether the LYMA Laser really works.
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